Glucosidase-beta variations and Lewy body disorders
نویسندگان
چکیده
منابع مشابه
Protein Clearance Mechanisms of Alpha-Synuclein and Amyloid-Beta in Lewy Body Disorders
Protein clearance is critical for the maintenance of the integrity of neuronal cells, and there is accumulating evidence that in most-if not all-neurodegenerative disorders, impaired protein clearance fundamentally contributes to functional and structural alterations eventually leading to clinical symptoms. Dysfunction of protein clearance leads to intra- and extraneuronal accumulation of misfo...
متن کاملBiomarkers in Alzheimer's Disease and Lewy Body Disorders with Dementia
1 Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwer Str. 14, 72076 Tuebingen, Germany Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 86 Stockholm, Sweden German Center for Neurodegenerative Diseases (DZNE), Otfried Müller-Strasse 27, 72076 Tuebingen, Germany 4 Section for Dementia Research, Hert...
متن کاملGlucocerebrosidase gene mutations: a risk factor for Lewy body disorders.
BACKGROUND Mutations in the glucocerebrosidase (GBA) gene have been reported to modify risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these findings have not been consistently replicated, and most studies have had substantial methodological shortcomings. OBJECTIVE To better assess the role of GBA variants in altering risk for Lewy body disorders. DESIGN Case-c...
متن کاملImpairment of script comprehension in Lewy body spectrum disorders.
A disabling impairment of higher-order language function can be seen in patients with Lewy body spectrum disorders such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB). We focus on script comprehension in patients with Lewy body spectrum disorders. While scripts unfold sequentially, constituent events are thought to contain an internal organi...
متن کاملDecision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders
Background: Lewy body disorders (LBD) are clinical syndromes characterized by pathological inclusions containing α-synuclein. Cognitive deficits are common or diagnostic in LBD, and may be associated with the presence of beta-amyloid (Aβ), which is a hallmark histopathologic abnormality characteristic of Alzheimer's disease (AD) that can also co-occur with LBD. Objective: In the present study w...
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ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2009
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2008.08.004